KMID : 0939920150470020329
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´ëÇѾÏÇÐȸÁö 2015 Volume.47 No. 2 p.329 ~ p.333
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Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma
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:Chung Jae-Heun
:Baik Seung-Kug/:Cho Su-Hee/:Kim Seong-Geun
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Abstract
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A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine region, sparing the basis pontis. Here, we report on the case of a patient with reversible cerebellar ataxia related to extrapontine myelinolysis without hyponatremia after treatment with cisplatin-based chemotherapy for cholangiocarcinoma and discuss the literature on cerebellar ataxia in patients who underwent recent chemotherapy for malignancy.
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KEYWORD
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Cisplatin, Myelinolysis, Central pontine, Hyponatremia, Cerebellar ataxia
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